Organocatalytic one-pot asymmetric synthesis of thiolated spiro-γ-lactam oxindoles bearing three stereocenters.

DOI Number:

10.1021/acs.joc.6b00653
Link to literature

Reaction Category:

Cascade reaction

Educt:

substituted ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, thiols, aldehydes, primary amines

Product:

thiolated spiro-γ-lactam oxindoles

Catalyst:

N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]- N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluorooctyl)phenyl]-thiourea

Cas No:

1456767-79-5

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7