Catalytic Asymmetric Aza-Michael−Michael Addition Cascade: Enantioselective Synthesis of Polysubstituted 4-Aminobenzopyrans.

DOI Number:

10.1021/ol1031188
Link to literature

Reaction Category:

Cascade reaction

Educt:

2-aminophenol, ethyl (E)-3-(2-((E)-2-nitroprop-1-en-1-yl)phenoxy)acrylate

Product:

ethyl 2-((2S,3R,4S)-4-((2-hydroxyphenyl)amino)-3-methyl-3-nitrochroman-2-yl)acetate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0