An enantioselective approach toward 3, 4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids.

DOI Number:

10.1021/jo202221c
Link to literature

Reaction Category:

Cyclization | Lactonization

MOP ID:

MOP_0000561

Educt:

styrene-type carboxylic acids, N-bromosuccinimide

Product:

(3S)-substituted (R)-4-bromo-isochroman-1-one

Catalyst:

(9S)-6′-methoxy-9-[N-(2,4-dimethoxyphenyl)carbamothioate]-cinchonan-9-ol

Cas No:

1254701-94-4

Associated Product from Buchler GmbH:

Quinidine Base

Cas No:

56-54-2