Cinchona-Based Primary Amine-Catalyzed Asymmetric Cascade Aza-Michael–Aldol Reactions of Enones with 2-(1 H-Pyrrol-2-yl)-2-oxoacetates: Synthesis of Chiral Pyrrolizines with Multistereocenters.
DOI Number:
10.1021/jo4001614
Reaction Category:
MOP ID:
MOP_0000561
Educt:
(E)-4-substituted-but-3-en-2-one, substituted methyl 2-oxo-2-(1H-pyrrol-2-yl)acetate
Product:
3,5,6-trisubstituted methyl (1R,2R,3R)-2-acetyl-1-hydroxy-2,3-dihydro-1H-pyrrolizine-1-carboxylate
Catalyst:
(8α,9S)-6′-(2,2-dimethylpropoxy)-Cinchonan-9-amine
Cas No:
1425926-44-8
Associated Product from Buchler GmbH:
Cupreine Base
Cas No:
524-63-0