LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor
DOI Number:
10.1002/anie.201501394
Reaction Category:
RXNO ID:
RXNO_0000235
Educt:
tert-butyl (Z)-(4-chlorobenzylidene)carbamate, methyl 3-methyl-4-nitrobutanoate
Product:
methyl (4S,5R)-5-((tert-butoxycarbonyl)amino)-5-(4-chlorophenyl)-3-methyl-4-nitropentanoate
Catalyst:
(1S,2R,4S,5R)-1-benzyl-2-((R)-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide
Cas No:
1374880-10-0
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2