A concise enantioselective synthesis of l-(−)-733,061 and (2S, 3S)-methyl 3-aminopiperidine-2-carboxylate using catalytic enantioselective aza-Henry reaction as key step.

DOI Number:

10.1016/j.tet.2011.02.031

Reaction Category:

Educt:

substituted-tert-butyl(tosylmethyl)carbamate, tert-butyldimethyl(4-nitrobutoxy)silane

Product:

tert-butyl ((1R,2S)-5-((tert-butyldimethylsilyl)oxy)-1-substituted-2-nitropentyl)carbamate

Catalyst:

(8α,9R)-9-hydroxy-6′-methoxy-1-(phenylmethyl)-Cinchonanium chloride

Cas No:

67174-25-8

Cas No:

67174-25-8