A concise enantioselective synthesis of l-(−)-733,061 and (2S, 3S)-methyl 3-aminopiperidine-2-carboxylate using catalytic enantioselective aza-Henry reaction as key step.
DOI Number:
10.1016/j.tet.2011.02.031
Reaction Category:
RXNO ID:
RXNO_0000235
Educt:
substituted-tert-butyl(tosylmethyl)carbamate, tert-butyldimethyl(4-nitrobutoxy)silane
Product:
tert-butyl ((1R,2S)-5-((tert-butyldimethylsilyl)oxy)-1-substituted-2-nitropentyl)carbamate
Catalyst:
(8α,9R)-9-hydroxy-6′-methoxy-1-(phenylmethyl)-Cinchonanium chloride
Cas No:
67174-25-8
Associated Product from Buchler GmbH:
N-Benzylquininium Chloride
Cas No:
67174-25-8