Recyclable organocatalyst-promoted one-pot Michael/aza-Henry/lactamization reactions for fluorinated 2-piperidinones bearing four stereogenic centres.
DOI Number:
10.1039/C5RA15306A
Reaction Category:
Educt:
diethyl 2-fluoromalonate, (E)-(2-nitrovinyl)benzene, 4-bromobenzaldehyde, ammonium acetate
Product:
ethyl (3S,4S,5S,6R)-6-(4-bromophenyl)-3-fluoro-5-nitro-2-oxo-4-phenylpiperidine-3-carboxylate
Catalyst:
N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea
Cas No:
1456767-79-5
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7