Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083.

DOI Number:

10.1002/anie.201105970

Reaction Category:

RXNO ID:

RXNO_0000235

Educt:

6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, nitromethane

Product:

(R)-6-chloro-1-(4-methoxybenzyl)-4-(nitromethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Catalyst:

1-(4-((R)-(benzyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin- 2-yl)methyl)quinolin-6-yl)-3-(3,5-bis(trifluoromethyl)phenyl) thiourea

Cas No:

882166-37-2

Cas No:

2143936-34-7