A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel–Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols.

DOI Number:

10.1021/acs.orglett.5b02668

Reaction Category:

RXNO ID:

RXNO_0000369

Educt:

4,6-Bis(trifluoromethyl)-2(1H)-quinazolinone, 1-naphtol

Product:

(R)-4-(1-hydroxynaphthalen-2-yl)-4,6-bis(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Catalyst:

3-(9H-fluoren-9-ylamino)-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1821065-68-2

Cas No:

130-95-0