A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel–Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols.
DOI Number:
10.1021/acs.orglett.5b02668
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
4,6-Bis(trifluoromethyl)-2(1H)-quinazolinone, 1-naphtol
Product:
(R)-4-(1-hydroxynaphthalen-2-yl)-4,6-bis(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
Catalyst:
3-(9H-fluoren-9-ylamino)-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1821065-68-2
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0