First asymmetric total synthesis of (−)-antofine by using an enantioselective catalytic phase transfer alkylation.

DOI Number:

10.1021/ol0349007
Link to literature

Reaction Category:

Alkylation | alpha-Alkylation

MOP ID:

MOP_0000369

Educt:

tert-butyl 2-((diphenylmethylene)amino)acetate, 10-(bromomethyl)-2,3,6-trimethoxyphenanthrene

Product:

tert-butyl (S)-2-((diphenylmethylene)amino)-3-(3,6,7-trimethoxyphenanthren-9-yl)propanoate

Catalyst:

(8α,9R)-(8′′α,9′′R)-1,1′′-[2,7-naphthalenediylbis(methylene)]bis[10,11-dihydro-9-(2-propen-1-yloxy)-cinchonanium bromide

Cas No:

480427-57-4

Associated Product from Buchler GmbH:

Dihydrocinchonidine Base

Cas No:

485-64-3