Highly enantioselective synthesis of (R)-α-alkylserines via phase-transfer catalytic alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester using cinchona-derived catalysts. 

DOI Number:

10.1021/ol050228x

Reaction Category:

Educt:

tert-butyl 2-([1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole-4-carboxylate, allylbromide

Product:

tert-butyl (R)-2-([1,1'-biphenyl]-2-yl)-4-allyl-4,5-dihydrooxazole-4-carboxylate

Catalyst:

(8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro-9-(2-propen-1-yloxy)-Cinchonanium bromide

Cas No:

550358-96-8

Associated Product from Buchler GmbH:

Dihydrocinchonidine Derivative

Cas No:

485-64-3