Highly enantioselective synthesis of (R)-α-alkylserines via phase-transfer catalytic alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester using cinchona-derived catalysts.
DOI Number:
10.1021/ol050228x
Reaction Category:
MOP ID:
MOP_0000369
Educt:
tert-butyl 2-([1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole-4-carboxylate, allylbromide
Product:
tert-butyl (R)-2-([1,1'-biphenyl]-2-yl)-4-allyl-4,5-dihydrooxazole-4-carboxylate
Catalyst:
(8α,9R)-1-(9-anthracenylmethyl)-10,11-dihydro-9-(2-propen-1-yloxy)-Cinchonanium bromide
Cas No:
550358-96-8
Associated Product from Buchler GmbH:
Dihydrocinchonidine Base
Cas No:
485-64-3