Organocatalytic Asymmetric Synthesis of α-Trifluoromethyl Homoallylic Amine Derivatives from Trifluoromethyl-Containing Ketoimines and Isatin-Derived Morita-Baylis-Hillman Carbonates.
DOI Number:
10.1002/adsc.202201091
Reaction Category:
MOP ID:
MOP_0000369
Educt:
(Z)-3-((2,2,2-trifluoroethyl)imino)benzo[b]thiophen-2(3H)-one, tert-butyl (3-(1-cyanovinyl)-1-methyl-2-oxoindolin-3-yl) carbonate
Product:
2-((S)-1-methyl-2-oxo-3-((R)-2,2,2-trifluoro-1-(((Z)-2-oxobenzo[b]thiophen-3(2H)-ylidene)amino)ethyl)indolin-3-yl)acrylonitrile
Catalyst:
(8α,9R)-(8′′α,9′′R)-9,9′′-[1,4-Phthalazinediylbis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan] ((DHQ)2PHAL
Cas No:
140924-50-1
Associated Product from Buchler GmbH:
1,4-Bis(9-O-dihydroquininyl)phthalazine ((DHQ)2PHAL
Cas No:
140924-50-1