Catalytic asymmetric difluoroalkylation using in situ generated difluoroenol species as the privileged synthon.
DOI Number:
10.1002/advs.202307520
Reaction Category:
MOP ID:
MOP_0000369
Educt:
(1-diazo-trifluoroethyl)benzene, water, N-protected indoline-2,3-dione
Product:
N-protected (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxyindolin-2-one
Catalyst:
rhodium catalyst, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea
Cas No:
957770-66-0
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea
Cas No:
957770-66-0