Acyl phosphonates: Good hydrogen bond acceptors and ester/amide equivalents in asymmetric organocatalysis.

DOI Number:

10.1021/ja9097803
Link to literature

Reaction Category:

Addition

Educt:

dimethyl (E)-but-2-enoylphosphonate, 2-(2-bromophenyl)-4-isopropyloxazol-5(4H)-one, methanol

Product:

methyl (R)-3-((R)-2-(2-bromophenyl)-4-isopropyl-5-oxo-2,5-dihydrooxazol-2-yl)butanoate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0