Highly Diastereo- and Enantioselective Formal [4 + 2] Cyclization of Nitroalkenes and Unsaturated Ketoesters under Phase-Transfer Catalysis.

DOI Number:

10.1021/acs.orglett.2c03418
Link to literature

Reaction Category:

[4+2]-Cycloaddition | Cascade reaction | Cycloaddition

MOP ID:

MOP_0000565

Educt:

ethyl (Z)-2-acetyl-4-phenylbut-2-enoate, ethyl (Z)-3-hydroxy-2-((E)-styryl)but-2-enoate, (E)-(2-nitrovinyl)benzene

Product:

ethyl (1'S,2'S,5'R,6'S)-5'-hydroxy-5'-methyl-6'-nitro-1',2',5',6'-tetrahydro-[1,1':2',1''-terphenyl]-4'-carboxylate

Catalyst:

(8α,9R)-1-[(2-fluoro-3-methylphenyl)methyl]-10,11-dihydro-9-hydroxy-6′-methoxy-Cinchonanium bromide

Cas No:

2865177-88-2

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7