Asymmetric synthesis of dihydrocoumarins via catalytic sequential 1, 6-addition/transesterification of α-isocyanoacetates with para-quinone methides.

DOI Number:

10.1039/C9OB02652E
Link to literature

Reaction Category:

Addition

Educt:

substituted 2,6-di-tert-butyl-4-(2-hydroxybenzylidene)cyclohexa-2,5-dien-1-one, substituted 2-cyanoacetate

Product:

3-substituted (4R)-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxochromane-3-carbonitrile

Catalyst:

N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide

Cas No:

1808117-30-7

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7