Organocatalytic Asymmetric [3+2] Cycloaddition of N‑2,2,2-Trifluoroethylisatin Ketimines with β‑Trifluoromethyl Electron- Deficient Alkenes: Access to Vicinally Bis(trifluoromethyl)-Substituted 3,2′-Pyrrolidinyl Spirooxindoles.
DOI Number:
10.1021/acs.orglett.8b01730
Reaction Category:
MOP ID:
MOP_0000715
Educt:
(Z)-1-benzyl-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, (E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one
Product:
(3S,3'S,4'S,5'S)-3'-benzoyl-1-benzyl-4',5'-bis(trifluoromethyl)spiro[indoline-3,2'-pyrrolidin]-2-one
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0