Chiral squaramides catalyzed diastereo-and enantioselective Michael addition of α-substituted isocyanoacetates to N-aryl maleimides.
DOI Number:
10.1016/j.tet.2013.09.084
Reaction Category:
MOP ID:
MOP_0000715
Educt:
α-substituted isocyanoacetates, N-substituted 1H-pyrrole-2,5-dione
Product:
1,5-substituted (1S,3aS,6aR)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate
Catalyst:
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]- 4-[(9R)-cinchonan-9-ylamino]-3- cyclobutene-1,2-dione
Cas No:
1256245-82-5
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5