Synthesis of Letermovir by an Asymmetric Aza-Michael Reaction.
DOI Number:
10.1021/acs.oprd.6b00076
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
methyl (2E)-3-(3-fluoro-2-((((2-methoxy-5-(trifluoromethyl)phenyl)amino)(4-(3-methoxyphenyl)piperazin-1-yl)methylene)amino)phenyl)acrylate
Product:
methyl (S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate
Catalyst:
N-[3,5-bis(trifluoromethyl)benzyl]-N'-[3-(trifluoromethyl)benzyl]-cinchonidinium Bromide
Cas No:
1791412-20-8
Associated Product from Buchler GmbH:
N-[3,5-bis(trifluoromethyl)benzyl]-N'-[3-(trifluoromethyl)benzyl]-cinchonidinium Bromide
Cas No:
1791412-20-8