Cinchona alkaloid derived squaramide catalyzed diastereo- and enantioselective Michael addition of isocyanoacetates to 2-enoylpyridines.
DOI Number:
10.1016/j.tet.2019.01.024
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
alpha-substituted isocyanoacetates, 2-enoylpyridines
Product:
substituted-2-substituted-2-cyano-3-substituted-5-oxo-5-(pyridin-2-yl)pentanoate
Catalyst:
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1352957-59-5
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7