Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.
DOI Number:
10.1039/C4OB00203B
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
alpha,beta-unsaturated ketones, diethyl malonate
Product:
diethyl 2-(1-substituted-3-substituted-3-oxopropyl)malonate
Catalyst:
N-[(1R)-2-Hydroxy-1-phenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
1608117-06-1
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0