Enantioselective Tandem Michael Addition and Cyclization Reaction Enabled by Dual Organo/Copper Catalysis: Access to Functionalized 4 H-Pyrans.

DOI Number:

10.1021/acs.orglett.5c05003
Link to literature

Reaction Category:

[4+2] Annulation | Cascade reaction | Cyclization | Further Cyclizations | Michael | Michael Addition

MOP ID:

MOP_0000561

Educt:

substituted 3-nitrohex-2-en-4-yne, alpha-nitrilketones

Product:

4 H-pyrans

Catalyst:

copper(II) acetate, BINAP, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7