Enantioselective synthesis of (R)-α-alkylhomoserines and (R)-α-alkylhomocysteines via phase-transfer catalytic alkylation.

DOI Number:

10.1055/s-0028-1087808
Link to literature

Reaction Category:

Alkylation | alpha-Alkylation

MOP ID:

MOP_0000369

Educt:

tert-butyl 2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate, 1-(bromomethyl)-4-fluorobenzene

Product:

tert-butyl (R)-4-(4-fluorobenzyl)-2-phenyl-5,6-dihydro-4H-1,3-oxazine-4-carboxylate

Catalyst:

(8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)-1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide

Cas No:

479617-92-0

Associated Product from Buchler GmbH:

Dihydrocinchonidine Base

Cas No:

485-64-3