The Ir-catalyzed asymmetric hydrogenation of α-halogenated ketones utilizing cinchona-alkaloid-derived NNP ligand to produce (R)-and (S)-halohydrins.

DOI Number:

10.1021/acs.joc.2c02109
Link to literature

Reaction Category:

Hydrogenation | Hydrogenation of ketones

MOP ID:

MOP_0000589

Educt:

α-halogenated ketones, hydrogen

Product:

2-halogen alcohols

Catalyst:

iridium catalyst, (S)-N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methoxyquinolin-4-yl)-1-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine

Cas No:

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0