Stereoselective synthesis of 2-trifluoromethylated and 2-difluoromethylated dihydrofurans via organocatalytic cascade Michael/alkylation reaction.

DOI Number:

10.1039/D1QO00367D

Reaction Category:

Educt:

ethyl 4,4,4-trifluoro-3-oxobutanoate, (E)-(2-bromo-2-nitrovinyl)benzene

Product:

2-trifluoromethylated dihydrofurans

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1210360-60-3

Associated Product from Buchler GmbH:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1210360-60-3