Catalytic enantioselective synthesis of carboxy-substituted 2-isoxazolines by cascade oxa-Michael-cyclization.

DOI Number:

10.1039/C7OB02722B
Link to literature

Reaction Category:

Cyclization | Isoxazoline cyclization | Michael Addition | Oxa-Michael Addition

MOP ID:

MOP_0000561

Educt:

2,4-disubstituted tert-butyl (Z)-4-oxobut-2-enoate, hydroxylamine

Product:

carboxy-substituted 2-isoxazolines

Catalyst:

N-[2,5-bis(trifluoromethyl)benzyl]-quinidinium Bromide

Cas No:

-

Associated Product from Buchler GmbH:

N-[2,5-bis(trifluoromethyl)benzyl]-quinidinium Bromide

Cas No:

-